Genotyping using ProQuant – you can but you shouldn’t! One of the fantastic resources we have here at RxCelerate is our tissue BioBank. One set of samples contained within it was a set of longitudinal serum and plasma samples taken from healthy volunteers....
Combined analysis of cleavage sites and glycosylation in a complex mixture In one of our complex datasets in which we analysed 30 human serum samples using ProQuant™ we noticed that the serum protein hemopexin was found with a range of residues lost from its...
ProQuant™ is precise, but is it accurate as well? All of our experimental optimisations during the development of the ProQuant™ proteomics platform were aimed at improving the precision of the method. We have already shown the marked effect that our proprietary...
Biomarkers of ageing One of the more obvious uses of ProQuant™ is to look for biomarkers of disease. We used ProQuant™ to investigate potential biomarkers of ageing, using serum samples from subjects of different ages. Across the 300 proteins measured none were...
Delving into proteoforms with higher throughput ProQuant™ was used to study apolipoprotein E (apoE), a polymorphic protein with key roles in longevity and Alzheimer’s disease. Our experiments testing different samples from in vitro and in vivo experiments identified...
